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Welcome to the web site of
The core meiotic
transcriptome in budding yeasts
Michael
Primig*, Roy M. Williams*, Elizabeth A. Winzeler,
Gela G. Tevzadze,
Andrew A. Conway, Seung Y. Hwang, Ronald W. Davis
and Rochelle E. Esposito
*These
authors contributed equally to this study
Nat
Genet. (2000), vol 4, p. 415-23
[PubMed] [Full text] [PDF]
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| We used high-density
oligonucleotide microarrays to analyse the genomes and meiotic expression
patterns of two yeast strains, SK1 and W303, that display distinct kinetics
and efficiencies of sporulation. Hybridization of genomic DNA to
arrays revealed numerous gene deletions and polymorphisms in both backgrounds.
The expression analysis yielded ~1600 meiotically regulated genes in each
strain, with a core set of ~60% displaying similar patterns in both strains.
Most of these (95%), are MATa/MATalpha-dependent and are not
similarly expressed in near isogenic meiosis-deficient controls.
The transcript profiles correlate with the distribution of defined meiotic
promoter elements and with time of known gene function. |
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